The grapefruit and the orange are definitely cousins, but they couldn't be more different in terms of flavor. Grapefruit is bitter, slightly tart, and sour, with a hint of sweetness thrown in. You'll notice grapefruit isn't always the go-to fruit when it comes to mixing cocktails, but that's only because you haven't mixed it with tequila yet! El Barrio | Grapefruit Margarita I first stumbled upon this simple, yet delicious grapefruit margarita in Birmingham, AL at this fabulous little taqueria ... Read More about Refreshing Grapefruit Margarita